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商品详细axonmedchem/4-CPPC/5 mg/Axon 3189
axonmedchem/4-CPPC/5 mg/Axon 3189
axonmedchem/4-CPPC/5 mg/Axon 3189
商品编号: Axon3189
品牌: axon medch
市场价: ¥2700.00
美元价: 1350.00
产地: 美国(厂家直采)
公司:
产品分类: 多肽合成
公司分类: peptide
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

4-CPPC

Based on 2 reference(s) in Google Scholar8102

Axon 3189

CAS [29553-70-6]

MF C14H9NO6MW 287.22

  • Purity:99%
  • Soluble in 0.1N NaOH(aq) and DMSO
Recently added

4-CPPC

Description

4-CPPC is the first potent, selective and reversible inhibitor of pro-inflammatory protein macrophage migration inhibitory factor-2 (MIF-2 or D-DT) with a Ki value of 33 μM and an IC50 value of 27 μM. 4-CPPC shows competitive binding with a 13-fold selectivity for human MIF-2 versus human MIF-1.

KEYWORDS: 4-CPPC | supplier | MIF-2 inhibitor | 4CPPC | 4 CPPC | CAS [29553-70-6] | p-Hydroxyphenyl-pyruvate (HPP) | Phenylpyruvate | MIF-2 | Inhibitor | Receptors

G Pantouris et al. Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor. Biochemistry. 2018 Jul 3;57(26):3599-3605.
PV Tilstam et al. A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity. J Biol Chem. 2019 Dec 6;294(49):18522-18531.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Signaling & OncologyImmunologyPain & InflammationTranscription FactorsUnclassifiedMIF
First potent, selective and reversible inhibitor of MIF-2

Chemical name

4-(3-Carboxyphenyl)pyridine-2,5-dicarboxylic acid

Parent CAS No.

[29553-70-6]

品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来,是欧洲**的化学服务平台,专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织(CRO)进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源,提供药品研究用的Axon Ligands (TM)系列。