Azoramide
Axon 2567
CAS [932986-18-0]
MF C15H17ClN2OSMW 308.83
- Purity:99%
- Soluble in DMSO
Description
Small-molecule modulator of the unfolded protein response (UPR) with antidiabetic activity (IC50 value 8.826 µM for azoramide-induced increase of ASGR-Cluc secretion in HuH7 cells). Azoramide is a dual-function ER modulator that improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress. Moreover, Azoramide improves insulin sensitivity and pancreatic β-cell function in multiple obese mouse preclinical models.
KEYWORDS: Azoramide | supplier | UPR modulator | CAS [932986-18-0] | Unfolded Protein Response | endoplasmatic reticulum | ER stress | protein folding | PERK | IRE1 | ATF6 | obesity | antidiabetic | glucose
| S Fu et al. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci Transl Med. 2015 Jun 17;7(292):292ra98. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyramide
Parent CAS No.
[932986-18-0]
