axonmedchem/AR7-非典型维甲酸7/10 mg/Axon 2679
商品编号：
Axon2679
品牌：
axon medch
市场价：
¥1800.00
美元价：
900.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AR7 - Atypical retinoid 7
Axon 2679
CAS [80306-38-3]
MF C15H12ClNOMW 257.71
- Purity:99,7%
- Soluble in DMSO
Description
Atypical RARα receptor antagonist that stimulates CMA (chaperone-mediated autophagy) activity without detectable changes in other autophagic pathways, making cells more resistant to oxidative stress and proteotoxicity. AR7 is also known as a hypoxia targeted compound for cancer therapeutics (IC50 value 10 μM for inhibition of hypoxic cancer cell growth (MTT assay) in HepG2 cells while sparing ‘normoxic’ cells).
KEYWORDS:AR7 | supplier | RARα antagonist | Atypical retinoid 7 | AR-7 | AR 7 | CAS [80306-38-3] | Retinoic Acid | nuclear receptor | NR1B1 | chaperone-mediated | autophagy | CMA | hypoxia | cancer | neurodegenerative
| BC Das et al. Design, synthesis and biological evaluation of 2H-benzo[b][1,4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4204-6. |
| J Anguiano et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9(6):374-82. |
- Certificate of Analysis
- Material Safety Data Sheet
ApoptosisCell Cycle RegulationCell Signaling & OncologyCNSRetinoic Acid (RAR)NR1BAutophagy
RARα antagonist that stimulates chaperone-mediated autophagy
Chemical name
7-chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine
Parent CAS No.
[80306-38-3]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
