axonmedchem/AGI 6780/5毫克/轴突2274
商品编号：
Axon2274
品牌：
axon medch
市场价：
¥1800.00
美元价：
900.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AGI 6780
Axon 2274
CAS [1432660-47-3]
MF C21H18F3N3O3S2MW 481.51
- Purity:99%
- Soluble in DMSO
Description
Inhibitor of isocitrate dehydrogenases (IDH) selective for mutant IDH2.AGI 6780 potently and selectively inhibits the tumor-associated mutant IDH2/R140Q (EC50 value <20 nm="" for="" reduction="" of="" 2hg="" levels="" in="" cell="" lines)="" in="" an="" allosteric="" manner="" at="" the="" dimer="" interface,="" and="" induces="" differentiation="" of="" tf-1="" erythroleukemia="" and="" primary="" human="" acute="" myelogenous="" leukemia="" cells="" in="" vitro.="">
| F. Wang et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013, 340, 622-626. |
- Certificate of Analysis
- Material Safety Data Sheet
Cell Signaling & OncologyDiabetes & MetabolismEpigeneticsEC 1.1.1.42Stem Cell DifferentiatorIDH
Potent and selective inhibitor of the tumor-associated mutant IDH2 (R140Q)
Chemical name
N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide
Parent CAS No.
[1432660-47-3]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
