axonmedchem/AGI 5198-IDH-C35/2毫克/轴突2122
商品编号：
Axon2122
品牌：
axon medch
市场价：
¥1200.00
美元价：
600.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AGI 5198 - IDH-C35
Axon 2122
CAS [1355326-35-0]
MF C27H31FN4O2MW 462.56
- Purity:100%
- Soluble in DMSO
Description
Potent inhibitor of mutant isocitrate dehydrogenase 1 (IDH1); selective for IDH1 R132H and R132C mutants in vitro with IC50 values of 0.07 and 0.16 µM, respectively; it delays growth and promotes differentiation of glioma cells.
KEYWORDS: AGI 5198 | supplier | IDH1 inhibitor | IDH-C35 | CAS [1355326-35-0] | Isocitrate | IDH | Inhibitor | Enzymes
| D Rohle et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science, 2013, 340(6132), 626-630. |
| FE Garrett-Bakelman and AM Melnick. Differentiation therapy for IDH1/2 mutant malignancies. Cell Res. 2013, 23, 975–977. |
- Certificate of Analysis
- Material Safety Data Sheet
Cell Signaling & OncologyDiabetes & MetabolismEC 1.1.1.42Stem Cell DifferentiatorIDH
Inhibitor of R132 mutant isocitrate dehydrogenase 1 (IDH1)
Chemical name
N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-o-tolylacetamide
Parent CAS No.
[1355326-35-0]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
