axonmedchem/Barbadin/10毫克/Axon 2774
商品编号：
Axon2774
品牌：
axon medch
市场价：
¥2200.00
美元价：
1100.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Barbadin
Axon 2774
CAS [356568-70-2]
MF C19H15N3OSMW 333.41
- Purity:99%
- Soluble in DMSO
Description
Selective β-arrestin/β2-adaptin interaction inhibitor (IC50 values of 19.1 and 15.6 μM for β-arrestin1 and β-arrestin2, respectively). Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors, but does not affect β-arrestin-independent (transferrin) or AP2-independent (endothelin-A) receptor internalization.
KEYWORDS: Barbadin | supplier | β-Arrestin/β2-Adaptin inhibitor | CAS [356568-70-2] | AP2 | β-Arrestin | Inhibitor | Proteins | GPCR | β2-Adrenergic | V2-Vasopressin | Angiotensin-II type-1 | Transferrin | Endothelin-A
| A Beautrait et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. |
- Certificate of Analysis
- Material Safety Data Sheet
Cell Signaling & OncologyMiscellaneousMAPKβ-Arrestin
β-Arrestin/β2-Adaptin inhibitor
Chemical name
3-Amino-5-(4-benzylphenyl)thieno[2,3-d]pyrimidin-4(3H)-one
Parent CAS No.
[356568-70-2]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
