axonmedchem/ABT 199-GDC 0199 | Venetoclax/5毫克/Axon 2141
商品编号：
Axon2141
品牌：
axon medch
市场价：
¥1800.00
美元价：
900.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
ABT 199 - GDC 0199 | Venetoclax
Axon 2141
CAS [1257044-40-8]
MF C45H50ClN7O7SMW 868.44
- Purity:98%
- Soluble in DMSO
Description
A highly potent, orally bioavailable BCL-2-selective inhibitor; a new Bcl-2–specific BH3 mimetic efficacious in vivo against mouse lymphomas without provoking thrombocytopenia.
KEYWORDS: ABT 199 | supplier | Bcl-2 inhibitor | GDC 0199 | Venetoclax | ABT199 | GDC0199 | ABT-199 | GDC-0199 | CAS [1257044-40-8] | Non Selective | Bcl | Inhibitor | Proteins
| AJ Souers et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat. Med. 2013, 19(2), 202-208. |
| C Touzeau et al. The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma. Leukemia advance online publication 16 August 2013;doi: 10.1038/leu.2013.216. |
| CJ Vandenberg and S Cory. ABT-199, a new Bcl-2–specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia. Blood, 2013, 121(12), 2285-2288. |
- Certificate of Analysis
- Material Safety Data Sheet
ApoptosisCell Cycle RegulationCell Signaling & OncologyBcl
Potent, orally bioavailable BCL-2-selective inhibitor
Chemical name
2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(3-nitro-4-((tetrahydro-2H-pyran-4-yl)methylamino)phenylsulfonyl)benzamide
Parent CAS No.
[1257044-40-8]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
