axonmedchem/FQI 1/10毫克/轴突2157
商品编号：
Axon2157
品牌：
axon medch
市场价：
¥1900.00
美元价：
950.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
FQI 1
Axon 2157
CAS [599151-35-6]
MF C18H17NO4MW 311.33
- Purity:99%
- Soluble in DMSO
Description
Antiproliferative small-molecule inhibitor of α-globin transcription factor CP2 (a.k.a. LSF; IC50 2.1 μM); cell-permeable, potent, specific, and reversible.FQI 1 induces cell death in LSF-overexpressing cells, including Hepatocellular carcinoma (HCC cells). FQI 1 inhibits LSF DNA-binding activity both in vitro and in vivo and also inhibits HCC tumor growth in a mouse xenograft model.
| T.J. Granta et al. Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma. PNAS 2012, 109, 4503–4508. |
| H.C. Kang et al. Erythroid Cell-Specific α-Globin Gene Regulation by the CP2 Transcription Factor Family. Mol. Cell. Biol. 2005, 25, 6005–6020. |
- Certificate of Analysis
- Material Safety Data Sheet
Cell Cycle RegulationCell Signaling & OncologyCNSImmunologyPain & InflammationCP2Transcription FactorsTF class 4
Inhibitor of α-globin transcription factor CP2 (LSF)
Chemical name
8-(2-ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one
Parent CAS No.
[599151-35-6]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
