axonmedchem/FDI 6-NCGC 00099374/10毫克/轴突2384
商品编号：
Axon2384
品牌：
axon medch
市场价：
¥1980.00
美元价：
990.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
FDI 6 - NCGC 00099374
Axon 2384
CAS [313380-27-7]
MF C19H11F4N3OS2MW 437.43
- Purity:99%
- Soluble in DMSO
Description
Inhibitor of the Forkhead box protein M1 transcription factor (IC50 value 22.5 µM for inhibiting FOXM1-DNA binding). FDI6 displaces FOXM1 from genomic targets in MCF-7 breast cancer cells, and induces concomitant transcriptional downregulation. FDI-6 is inactive against the proteasome, and concordance between its biophysical IC50 and cellular GI50 values (22.5 μM and 18.0 μM, respectively) suggests it does not suffer from the off-target effects of thiostrepton.
| M.V. Gormally et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014 Nov 12;5:5165. |
| G. Marsico et al. Small molecule inhibition of FOXM1: How to bring a novel compound into genomic context. Genomics Data 3 (2015) 19-23. |
- Certificate of Analysis
- Material Safety Data Sheet
Cell Cycle RegulationCell Signaling & OncologyEpigeneticsTranscription FactorsFOXM1TF class 3.3.1
Inhibitor of the Forkhead box protein M1 (FOXM1)
Chemical name
3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide
Parent CAS No.
[313380-27-7]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
