axonmedchem/EVP 4593/10毫克/Axon 2080
商品编号：
Axon2080
品牌：
axon medch
市场价：
¥2200.00
美元价：
1100.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
EVP 4593
Axon 2080
CAS [545380-34-5]
MF C22H20N4OMW 356.42
- Purity:99%
- Soluble in DMSO
Description
Potent NF-κB activation inhibitor (EC50: 9 nM); inhibits SOC pathway in HD neurons; exerts neuroprotective effects in transgenic HD flies and transgenic HD mouse neurons. EVP4593 was not active when tested in the IKK kinase assay
| J Wu et al. Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington"s disease treatment. Chem. Biol. 2011, 18(6), 777-793. |
| M Tobe et al. A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives. Bioorg. Med. Chem. 2003, 11, 3869–3878. |
- Certificate of Analysis
- Material Safety Data Sheet
CardiovascularCell Signaling & OncologyCNSImmunologyPain & InflammationTranscription FactorsNF-κBL-TypeNF-κB
NF-κB activation inhibitor; inhibits SOC pathway
Chemical name
N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine
Parent CAS No.
[545380-34-5]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
