axonmedchem/COTI-2/10毫克/轴突2841
商品编号：
Axon2841
品牌：
axon medch
市场价：
¥2500.00
美元价：
1250.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
COTI-2
Axon 2841
CAS [1039455-84-9]
MF C19H22N6SMW 366.48
- Purity:99%
- Soluble in 0.1N HCl(aq) and DMSO
Description
COTI-2 is an anti-cancer drug which appears to act both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. Proposed to cause cancer cell death via apoptosis. COTI-2 exhibits potent anti-proliferative activity against a wide variety of human cancer cell lines in vitro (at nanomolar concentrations) and against human tumor xenografts.
KEYWORDS: COTI-2 | supplier | p53 activator | COTI2 | COTI 2 | CAS [1039455-84-9] | DNA-RNA | p53 | Activator | Transcription Factors
| KY Salim et al. COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo. Oncotarget. 2016 Jul 5;7(27):41363-41379. |
| MJ Duffy et al. Mutant p53 as a target for cancer treatment. Eur J Cancer. 2017 Sep;83:258-265. |
| S Maleki Vareki et al. Novel anti-cancer drug COTI-2 synergizes with therapeutic agents and does not induce resistance or exhibit cross-resistance in human cancer cell lines. PLoS One. 2018 Jan 24;13(1):e0191766. |
- Certificate of Analysis
- Material Safety Data Sheet
ApoptosisCell Signaling & Oncologyp53Transcription Factorsp53-Tumor SuppressionPI3K-Akt-mTORTF class 4.3.1
Reactivator of mutant p53
Chemical name
N"-(6,7-Dihydroquinolin-8(5H)-ylidene)-4-(pyridin-2-yl)piperazine-1-carbothiohydrazide
Parent CAS No.
[1039455-84-9]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
