CCT251236
Axon 2699
CAS [1693731-40-6]
MF C32H32N4O5MW 552.62
- Purity:99%
- Soluble in 0.1N HCl(aq) and DMSO
Description
Highly potent, orally bioavailable inhibitor of the HSF1 stress pathway. CCT251236 displayed the desired balance of in vitro properties, while maintaining excellent cellular activity for inhibition of HSF1-mediated HSP72 induction (IC50 value of 19 nM). Moreover, CCT251236 displayed efficacy in a human ovarian carcinoma xenograft model. Promising chemical probe to investigate the role of HSF1 pathway inhibition and pirin binding in vitro and in vivo.
KEYWORDS: CCT251236 | supplier | HSF1 inhibitor | CCT 251236 | CCT-251236 | CAS [1693731-40-6] | DNA-RNA | HSF1 | Inhibitor | Transcription Factors | HSP72 | Pirin
| MD Cheeseman et al. Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. J Med Chem. 2017 Jan 12;60(1):180-201. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
N-(5-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide
Parent CAS No.
[1693731-40-6]
