axonmedchem/芸薹素/10毫克/轴突2489
商品编号：
Axon2489
品牌：
axon medch
市场价：
¥1500.00
美元价：
750.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Brassinin
Axon 2489
CAS [105748-59-2]
MF C11H12N2S2MW 236.36
- Purity:98%
- Soluble in DMSO
Description
Bioavailable dithiocarbamate with affinity for indoleamine 2,3-dioxygenase (IDO; Ki value 28 μM for human IDO) showing antifungal and anticancer activity. Moreover, Brassinin suppressed both constitutive and IL-6-inducible STAT3 activation through modulation of PIAS-3 and SOCS-3, thereby attenuating tumor growth and increasing sensitivity to paclitaxel.
KEYWORDS: Brassinin | supplier | Dual IDO1/STAT3 inhibitor | CAS [105748-59-2] | L-Kynurenine | IDO1 | STAT3 | Inhibitor | IL-6 | PIAS-3 | SOCS-3 | antifungal | anticancer | natural | dithiocarbamate | paclitaxel
| T. Banerjee et al. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene. 2008 May 1;27(20):2851-7. |
| P. Gaspari et al. Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2006 Jan 26;49(2):684-92. |
| J.H. Lee et al. Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel. Oncotarget. 2015 Mar 20;6(8):6386-405. |
- Certificate of Analysis
- Material Safety Data Sheet
ApoptosisCell Signaling & OncologyImmunologyIDO1Transcription FactorsJAK-STATTF class 4.2.1EC 1.13.11.52STAT3
Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity
Chemical name
methyl (1H-indol-3-yl)methylcarbamodithioate
Parent CAS No.
[105748-59-2]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
