axonmedchem/AS 1517499/10毫克/Axon 1992
商品编号：
Axon1992
品牌：
axon medch
市场价：
¥2500.00
美元价：
1250.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AS 1517499
Axon 1992
CAS [919486-40-1]
MF C20H20ClN5O2MW 397.86
- Purity:99%
- Soluble in DMSO
Description
Potent and selective STAT6 inhibitor (IC50: 21 nM)
KEYWORDS:AS 1517499 | supplier | STAT6 inhibitor | AS1517499 | AS-1517499 | CAS [919486-40-1] | DNA-RNA | STAT6 | Inhibitor | Transcription Factor | NF-κB | IL-13 | TNF-α | asthma | interleukin
| S Nagashima et al. Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg. Med. Chem. 2007, 15(2), 1044-1055. |
| Y Chiba et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am. J. Respir. Cell Mol. Biol. 2009, 41(5), 516-524. |
| K Goto et al. The proximal STAT6 and NF-κB sites are responsible for IL-13- and TNF-α-induced RhoA transcriptions in human bronchial smooth muscle cells. Pharmacol. Res. 2010, 61(5), 466–472. |
List of publications using AS 1517499 (Axon 1992) purchased from Axon Medchem
- Certificate of Analysis
- Material Safety Data Sheet
Cell Signaling & OncologyImmunologyStem CellSTAT6Transcription FactorsJAK-STATTF class 4.2.1
Potent and selective STAT6 inhibitor
Chemical name
4-(benzylamino)-2-(3-chloro-4-hydroxyphenethylamino)pyrimidine-5-carboxamide
Parent CAS No.
[919486-40-1]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
