axonmedchem/AVE 0118盐酸盐/5毫克/Axon 2243
商品编号：
Axon2243
品牌：
axon medch
市场价：
¥2400.00
美元价：
1200.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AVE 0118 hydrochloride
Axon 2243
CAS [498577-53-0 (parent)]
MF C30H29N3O3.HClMW 516.03
- Purity:99%
- Soluble in water and DMSO
Description
Potassium channel blocker. AVE0118 caused concentration-dependent inhibition of Kv1.5 (IKur), Kv4.3 (Ito),Kir3.4 (IKAch), and IKr currents (IC50 values 6.2 μM,3.4 μM, 4.5 μM, and 10 μM resp.). A potent and atrium selective antiarrhythmic compound with no apparent effect on ventricular repolarization. Noteworthy, the atrial selective and dose-dependent prolongation of atrial refractoriness (ERP) by AVE 0118 has been claimed to be an inhibitory effect of sodium channel activity in an atrial-selective manner, and may therefor contribute to anti-AF properties of AVE0118.
| H. Gögelein et al. Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels. Naun. Schmiedebergs Arch. Pharmacol. 2004, 370, 183-192. |
| K.J. Wirth et al. Atrial effects of the novel K+-channel-blocker AVE0118 in anesthetized pigs. Cardiovascular Res. 2003, 60, 298-306. |
| A. Burashnikov et al. Atrial-selective prolongation of refractory period with AVE0118 is due principally to inhibition of sodium channel activity. J. Cardiovasc. Pharmacol. 2012, 59, 539-546. |
- Certificate of Analysis
- Material Safety Data Sheet
CardiovascularCell Signaling & OncologyCNSDiabetes & MetabolismPain & InflammationKv1.5Kv4.3Kir4.3KCND3KCNJ5KCNE1
Potassium channel blocker (Kv1.5 (IKur), Kv4.3 (Ito),Kir3.4 (IKAch), and IKr currents)
Chemical name
2"-((2-(4-methoxyphenyl)acetamido)methyl)-N-(2-(pyridin-3-yl)ethyl)biphenyl-2-carboxamide hydrochloride
Parent CAS No.
[498577-53-0]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
