axonmedchem/AT 1001/10毫克/轴突2401
商品编号:
Axon2401
品牌:
axon medch
市场价:
¥1900.00
美元价:
950.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
AT 1001
Axon 2401
CAS [1314801-63-2]
MF C15H21BrN2MW 309.24
- Purity:100%
- Optical purity:Relative stereochemistry
- Soluble in 0.1N HCl(aq) and DMSO
Description
High affinity and selective α3β4 nAChR ligand (Ki value 2.6 nM at α3β4 nAChR) with both partial agonistic and antagonistic effects, and >90-fold selective over the other major subtypes, the α4β2 and α7 nAChR. AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding, and shows a mechanism of action very different from varenicline (Axon 1384 (HCl salt) and Axon 2074 (tartrate salt)).
A. Cippitelli et al. AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology. Br J Pharmacol. 2015 Apr;172(7):1834-45. |
L. Toll et al. AT-1001: a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats. Neuropsychopharmacology. 2012 May;37(6):1367-76. |
E.W. Tuan et al. AT-1001 is a Partial Agonist with High Affinity and Selectivity at Human and Rat α3β4 Nicotinic Cholinergic Receptors. Mol Pharmacol. 2015 Jul 10. pii: mol.115.099978. [Epub ahead of print] |
- Certificate of Analysis
- Material Safety Data Sheet
CNSPain & InflammationnAChRUnclassified
High affinity and selective α3β4 nAChR ligand with partial agonistic and antagonistic effects
Chemical name
N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine
Parent CAS No.
[1314801-63-2]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来,是欧洲**的化学服务平台,专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织(CRO)进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源,提供药品研究用的Axon Ligands (TM)系列。