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商品详细axonmedchem/AT 1001/10毫克/轴突2401
axonmedchem/AT 1001/10毫克/轴突2401
axonmedchem/AT 1001/10毫克/轴突2401
商品编号: Axon2401
品牌: axon medch
市场价: ¥1900.00
美元价: 950.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
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商品介绍

AT 1001

Based on 16 reference(s) in Google Scholar91016

Axon 2401

CAS [1314801-63-2]

MF C15H21BrN2MW 309.24

  • Purity:100%
  • Optical purity:Relative stereochemistry
  • Soluble in 0.1N HCl(aq) and DMSO

AT 1001

Description

High affinity and selective α3β4 nAChR ligand (Ki value 2.6 nM at α3β4 nAChR) with both partial agonistic and antagonistic effects, and >90-fold selective over the other major subtypes, the α4β2 and α7 nAChR. AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding, and shows a mechanism of action very different from varenicline (Axon 1384 (HCl salt) and Axon 2074 (tartrate salt)).

A. Cippitelli et al. AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology. Br J Pharmacol. 2015 Apr;172(7):1834-45.
L. Toll et al. AT-1001: a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats. Neuropsychopharmacology. 2012 May;37(6):1367-76.
E.W. Tuan et al. AT-1001 is a Partial Agonist with High Affinity and Selectivity at Human and Rat α3β4 Nicotinic Cholinergic Receptors. Mol Pharmacol. 2015 Jul 10. pii: mol.115.099978. [Epub ahead of print]
  • Certificate of Analysis
  • Material Safety Data Sheet
CNSPain & InflammationnAChRUnclassified
High affinity and selective α3β4 nAChR ligand with partial agonistic and antagonistic effects

Chemical name

N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine

Parent CAS No.

[1314801-63-2]

品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来,是欧洲**的化学服务平台,专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织(CRO)进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源,提供药品研究用的Axon Ligands (TM)系列。