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商品详细axonmedchem/Adjudin-AF 2364/10毫克/轴突2552
axonmedchem/Adjudin-AF 2364/10毫克/轴突2552
axonmedchem/Adjudin-AF 2364/10毫克/轴突2552
商品编号: Axon2552
品牌: axon medch
市场价: ¥2500.00
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商品介绍

Adjudin - AF 2364

Based on 157 publications in PubMed910157

Axon 2552

CAS [252025-52-8]

MF C15H12Cl2N4OMW 335.19

  • Purity:99%
  • Soluble in DMSO

Adjudin

Description

Non-hormonal male contraceptive that exerts its effect by disrupting Sertoli-germ cell adhesion junctions, most notably apical ectoplasmic specialization (apical ES), by targeting testin and actin filament bundles that disrupt the actin-based cytoskeleton in Sertoli cells. Adjudin is a potent blocker of Cl- channels. Moreover, Adjudin is shown to induce apoptosis in cancer cells through a Caspase-3-dependent pathway, and triggers mitochondrial dysfunction in cancer cells, apparently affecting the mitochondrial mass, inducing the loss of mitochondrial membrane potential and reducing cellular ATP levels. Furthermore, Adjudin posesses anti-inflammation, anti-neurodegeneration, and anti-ototoxicity activities based on studies using different in vitro and in vivo models.

KEYWORDS: Adjudin | supplier | Male contraceptive | AF 2364 | AF2364 | CAS [252025-52-8] | Chloride | CFTR | Inhibitor | Ion Channels | fertility | actin | testin | Sertoli-germ | apical ectoplasmic specialization | cytoskeleton | blocker | apoptosis | Caspase-3 | mitochondrial | dysfunction | cancer cells | membrane potential | ATP

CY Cheng et al. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. Biol Reprod. 2001 Aug;65(2):449-61.
QR Xie et al. Male contraceptive Adjudin is a potential anti-cancer drug. Biochem Pharmacol. 2013 Feb 1;85(3):345-55.
K Li et al. Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans. Hum Reprod. 2013 Jan;28(1):47-59.
YH Cheng et al. Adjudin - A Male Contraceptive with Other Biological Activities. Recent Pat Endocr Metab Immune Drug Discov. 2015;9(2):63-73.
  • Certificate of Analysis
  • Material Safety Data Sheet
ApoptosisCardiovascularCell Signaling & OncologyCNSDiabetes & MetabolismMiscellaneousPain & InflammationCFTRNF-κBMAPKEC 3.6.3.49
Non-hormonal male contraceptive with anti-proliferative activity

Chemical name

1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide

Parent CAS No.

[252025-52-8]

品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来,是欧洲**的化学服务平台,专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织(CRO)进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源,提供药品研究用的Axon Ligands (TM)系列。