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商品详细axonmedchem/A2764二盐酸盐-TRESK抑制剂A2764
axonmedchem/A2764二盐酸盐-TRESK抑制剂A2764
axonmedchem/A2764二盐酸盐-TRESK抑制剂A2764
商品编号: Axon3019
品牌: axon medch
市场价: ¥2100.00
美元价: 1050.00
产地: 美国(厂家直采)
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产品分类: 聚合物
公司分类: juhewu
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商品介绍

A2764 dihydrochloride - TRESK inhibitor A2764

Based on 1 reference(s) in Google Scholar8101

Axon 3019

CAS [861038-72-4]

MF C15H19ClN2O.2HClMW 351.70

  • Purity:99%
  • Soluble in water and DMSO

A2764 dihydrochloride

Description

A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. The degree of inhibition by 100 µM A2764 was larger in the activated state of TRESK than in the resting state of the channel. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability.

KEYWORDS: A2764 dihydrochloride | supplier | TRESK inhibitor | A 2764 dihydrochloride | A-2764 dihydrochloride | CAS [861038-72-4] | [809248-52-0] | Potassium | TRESK | Inhibitor | Ion Channels | Migraine | Neuropathic pain | K2P18.1

M Lengyel et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660.
  • Certificate of Analysis
  • Material Safety Data Sheet
CNSPain & InflammationTRESKKCNK18
Selective inhibitor of the TRESK potassium channel

Chemical name

2-(5-Chloroquinolin-8-yloxy)-N,N-diethylethanamine dihydrochloride

Parent CAS No.

[809248-52-0]

品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来,是欧洲**的化学服务平台,专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织(CRO)进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源,提供药品研究用的Axon Ligands (TM)系列。