axonmedchem/A 804598/10毫克/轴突2182
商品编号：
Axon2182
品牌：
axon medch
市场价：
¥2500.00
美元价：
1250.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
A 804598
Axon 2182
CAS [1125758-85-1]
MF C19H17N5MW 315.37
- Purity:99%
- Optical purity:>99% e.e.
- Soluble in DMSO
Description
Potent and selective P2X7 antagonist (IC50 values 10 nM, 9 nM, and 11 nM for rat, mouse, and human receptors respectively). A 804598 potently blocked agonist stimulated release of IL-1β and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.In another study, A 804598 was found to produce a concentration-dependent inhibition of BZ-ATP-stimulated calcium influx (IC50 value 28.71 nM)in cells expressing the rat recombinant P2X7 receptor; a useful tool for autoradiographic localization of P2X7 receptors in the rat brain and spinal cord.
| D.L. Donnelly-Roberts et al. [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharm. 2009, 56, 223–229. |
| S.L. Able et al. Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat. Br. J. Pharmacol. 2011, 162, 405–414. |
- Certificate of Analysis
- Material Safety Data Sheet
ApoptosisCell Signaling & OncologyCNSPain & InflammationP2X7Unclassified
Potent and selective P2X7 antagonist
Chemical name
(S)-2-cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine
Parent CAS No.
[1125758-85-1]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
