axonmedchem/4BP-TQS/10毫克/轴突2694
商品编号：
Axon2694
品牌：
axon medch
市场价：
¥2100.00
美元价：
1050.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
4BP-TQS
Axon 2694
CAS [360791-49-7]
MF C18H17BrN2O2SMW 405.31
- Purity:99%
- Soluble in DMSO
Description
4BP-TQS is an allosteric agonist of α7 nicotinic acetylcholine receptors (nAChR). The agonism was shown to act through a site topographically distinct from the ACh site. 4BP-TQS was a more potent and efficacious agonist of α7 nAChR than ACh (8-fold lower EC50 and 45-fold larger maximal response).
The bioactive enantiomer of 4BP-TQS, GAT107 (Axon 2621), is also available.
KEYWORDS: 4BP-TQS | supplier | α7 nAChR allosteric agonist | 4BPTQS | 4-BPTQS | 4-BP-TQS | CAS [360791-49-7] | Acetylcholine | nAChR | Allosteric agonist | Ion Channels | CAS [1476053-27-6]
| JK Gill et al. Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc Natl Acad Sci USA. 2011 Apr 5;108(14):5867-72. |
| RL Papke. The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface. J Biol Chem. 2014 Feb 14;289(7):4515-31. |
- Certificate of Analysis
- Material Safety Data Sheet
CNSPain & InflammationnAChRUnclassified
Allosteric agonist of α7 nAChR
Chemical name
4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
Parent CAS No.
[360791-49-7]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
