axonmedchem/AC 264613/5毫克/轴突2898
商品编号：
Axon2898
品牌：
axon medch
市场价：
¥2090.00
美元价：
1045.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AC 264613
Axon 2898
CAS [1051487-82-1]
MF C19H18BrN3O2MW 400.27
- Purity:98%
- Soluble in DMSO
Description
AC 264613 is a potent, selective, and metabolically stable protease activated receptor 2 (PAR2) agonist (pEC50 value of 6.7). The potency of AC 264613 in the cellular proliferation assay was approximately 50 nM, and was virtually the same at wild-type PAR2 receptors. Incubation of macrophages with AC 264613 caused a decrease of IRF5 expression and also significantly reduced p53 protein expression.
KEYWORDS: AC 264613 | supplier | PAR2 agonist | AC-264613 | AC264613 | CAS [1051487-82-1] | Thrombin | Thrombin (PAR) | Agonist | Receptors
| JG Seitzberg et al. Discovery of potent and selective small-molecule PAR-2 agonists. J Med Chem. 2008 Sep 25;51(18):5490-3. |
| LR Gardell et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008 Dec;327(3):799-808. |
| R Yamaguchi et al. A protease-activated receptor 2 agonist (AC-264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages: Role of p53. Cell Biol Int. 2016 Jun;40(6):629-41. |
- Certificate of Analysis
- Material Safety Data Sheet
Diabetes & MetabolismMiscellaneousPain & InflammationA15Thrombin (PAR)
Potent, selective, and metabolically stable PAR2 agonist
Chemical name
N"-(1-(3-Bromophenyl)ethylidene)-2-oxo-4-phenylpyrrolidine-3-carbohydrazide
Parent CAS No.
[1051487-82-1]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
