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商品详细axonmedchem/AC 220二盐酸盐
axonmedchem/AC 220二盐酸盐
axonmedchem/AC 220二盐酸盐
商品编号: Axon1696
品牌: axon medch
市场价: ¥1800.00
美元价: 900.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

AC 220 dihydrochloride - Quizartinib dihydrochloride

Based on 52 publications in PubMed101052

Axon 1696

CAS [1132827-21-4]

MF C29H32N6O4S.2HClMW 633.59

  • Purity:98%
  • Soluble in DMSO

AC 220 dihydrochloride

Description

A uniquely potent, selective and efficacious inhibitor of FMS-Like Tyrosine kinase-3 (FLT3) for the treatment of AML; Second-generation FLT3 inhibitor that is highly potent with low nanomolar potency both in vitro and in cellular assays, and has a highly focused and selective interaction pattern across the human protein kinome.
PP Zarrinkar et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 2009, 114 (14), 2984-2992.
PH Wiernik. FLT3 inhibitors for the treatment of acute myeloid leukemia. Clin. Adv. Hematol. Oncol. 2010, 8(6), 429-444.
Q Chao et al. Identification of N-(5-tert-butyl-isoxazol-3-yl)-N"-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and (...). J. Med. Chem. 2009, 52(23), 7808-7816.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Signaling & OncologyFLT3RTK class III; EC 2.7.10.1
FLT3 inhibitor

Chemical name

1-(5-tert-Butyl-isoxazol-3-yl)-3-{4-[7-(2-morpholin-4-yl-ethoxy)-benzo[d]imidazo[2,1-b]thiazol-2-yl]-phenyl}-urea dihydrochloride

Parent CAS No.

[950769-58-1]

品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来,是欧洲**的化学服务平台,专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织(CRO)进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源,提供药品研究用的Axon Ligands (TM)系列。