A 83-01
Axon 1421
CAS [909910-43-6]
MF C25H19N5SMW 421.52
- Purity:99%
- Soluble in DMSO
Description
Potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 and its relatives ALK4 and ALK7 (IC50 to be 12, 45 and 7.5 nM respectively). A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β, but had no effect on BMP signaling; Used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state.
*Note: A 83-01 is found to decompose to A 77-01 (Axon 1744) in solution slowly. Hence freshly prepared solution is highly recommended and otherwise, its stock solution in DMSO needs to be stored <-20 °C (not longer than 1 month).
KEYWORDS:A 83-01 | supplier | ALK5 inhibitor | A83-01 | A8301 | CAS [909910-43-6] | TGF-β | TGF-βR | Antagonist | ALK4 | ALK7 | Smad | signaling | epithelial | mesenchymal | transition | iPS | self-renewal
| M Tojo et al. The ALK5 inhibitor A-83-01 inhibits smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer. Sci. 2005, 96, 791-800. |
| W. Li et al. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 2009, 4, 16-19. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide
Parent CAS No.
[909910-43-6]
