axonmedchem/A 77-01/5毫克/轴突1744
商品编号：
Axon1744
品牌：
axon medch
市场价：
¥1600.00
美元价：
800.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
A 77-01
Axon 1744
CAS [607737-87-1]
MF C18H14N4MW 286.33
- Purity:99%
- Soluble in DMSO
Description
Potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. A-77-01 is a close analogue of A-83-01 (Axon 1421) and has a very similar biological profile of A-83-01. A-83-01 is found to decompose to A-77-01 under certain circumstances and A-77-01 is likely an active component or metabolite of its prodrug A-83-01.
KEYWORDS:A 77-01 | supplier | ALK5 inhibitor | A77-01 | A7701 | CAS [607737-87-1] | TGF-β | TGF-beta | RSTK | Enzyme Linked Receptors | activin-like kinase | metabolite | A-83-01
| M Tojo et al. The ALK5 inhibitor A-83-01 inhibits smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer. Sci. 2005, 96, 791-800. |
- Certificate of Analysis
- Material Safety Data Sheet
ApoptosisCell Signaling & OncologyStem CellTGF-βRSTK class I; EC 2.7.11.30TGF-βR
TGF-βR 1 inhibitor; ALK 5 inhibitor
Chemical name
4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline
Parent CAS No.
[607737-87-1]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
