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商品详细axonmedchem/醋酸阿比特龙-CB 7630 | JNJ 212082
axonmedchem/醋酸阿比特龙-CB 7630 | JNJ 212082
axonmedchem/醋酸阿比特龙-CB 7630 | JNJ 212082
商品编号: Axon1874
品牌: axon medch
市场价: ¥1800.00
美元价: 900.00
产地: 美国(厂家直采)
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产品分类: 聚合物
公司分类: juhewu
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商品介绍

Abiraterone acetate - CB 7630 | JNJ 212082

Based on 14 reference(s) in Google Scholar81014

Axon 1874

CAS [154229-18-2]

MF C26H33NO2MW 391.55

  • Purity:100%
  • Optical purity:Optically pure
  • Poorly soluble in DMSO

Abiraterone acetate

Description

Orally administered prodrug of Abiraterone (Axon 1873); inhibitor of the steroidal enzyme 17 α-hydroxylase/C17,20 lyase (CYP17A1); a drug used in castration-resistant prostate cancer (CRPC)

G Attard et al. Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer. BJU Int. 2005, 96 (9), 1241–1246.
JE Ang et al. CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer. Br. J. Cancer 2009, 100(5), 671–675.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Signaling & OncologyDiabetes & MetabolismEndocrinologyEC 1.14.99.9Cytochrome P450
Prodrug of Abiraterone; Inhibitor of CYP17A1

Chemical name

(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

Parent CAS No.

[154229-18-2]

品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来,是欧洲**的化学服务平台,专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织(CRO)进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源,提供药品研究用的Axon Ligands (TM)系列。