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商品详细axonmedchem/ABC294640-Opaganib/10毫克/Axon 2880
axonmedchem/ABC294640-Opaganib/10毫克/Axon 2880
axonmedchem/ABC294640-Opaganib/10毫克/Axon 2880
商品编号: Axon2880
品牌: axon medch
市场价: ¥2500.00
美元价: 1250.00
产地: 美国(厂家直采)
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产品分类: 聚合物
公司分类: juhewu
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商品介绍

ABC294640 - Opaganib

Based on 63 reference(s) in Google Scholar81063

Axon 2880

CAS [915385-81-8]

MF C23H25ClN2OMW 380.91

  • Purity:98%
  • Soluble in 0.1N HCl(aq) and DMSO

ABC294640

Description

ABC294640 is a selective and orally available Sphingosine kinase 2 inhibitor (SphK2 or SK2) in vitro, acting as a competitive inhibitor with respect to sphingosine with a Ki of 9.8 μM, and attenuates S1P formation in intact cells. In tissue culture, ABC294640 suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments. ABC294640 shows in vivo SK inhibitory activity in mice. Drug candidate for the treatment of cancer and other diseases.

KEYWORDS: ABC294640 | supplier | SphK2 inhibitor | Opaganib | ABC 294640 | ABC-294640 | CAS [915385-81-8] | [1185157-59-8] | Sphingosine | SphK | Inhibitor | Enzymes | Ulcerative colitis | Crohn’s Disease | Inflammatory bowel disease

LW Maines et al. Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase. Dig Dis Sci. 2008 Apr;53(4):997-1012.
KJ French et al. Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther. 2010 Apr;333(1):129-39.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Signaling & OncologyImmunologyPain & InflammationEC 2.7.1.91SphK
Selective and orally available SphK2 (or SK2) inhibitor

Chemical name

3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide

Parent CAS No.

[915385-81-8]

品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来,是欧洲**的化学服务平台,专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织(CRO)进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源,提供药品研究用的Axon Ligands (TM)系列。