axonmedchem/A-196/10毫克/轴突2705
商品编号：
Axon2705
品牌：
axon medch
市场价：
¥2100.00
美元价：
1050.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
A-196
Axon 2705
CAS [1982372-88-2]
MF C18H16Cl2N4MW 359.25
- Purity:99%
- Soluble in 0.1N HCl(aq) and DMSO
Description
A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 ((IC50 values of 25 and 144 nM, respectively). In cells, A-196 induced a global decrease in H4K20me2 and H4K20me3 and a concomitant increase in H4K20me1. A-196 inhibited 53BP1 foci formation upon ionizing radiation and reduced NHEJ-mediated DNA-break repair but did not affect homology-directed repair.
KEYWORDS: A-196 | supplier | SUV4-20 inhibitor | A196 | A 196 | CAS [1982372-88-2] | Non Selective (Lysine Sites Proteins) | PKMT | Inhibitor | Enzymes | Protein Lysine Methyltransferase | Histone Methyltransferase | SUV420H1 | SUV420H2
| KD Bromberg et al. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol. 2017 Mar;13(3):317-324. |
- Certificate of Analysis
- Material Safety Data Sheet
Cell Signaling & OncologyEpigeneticsEC 2.1.1.43PKMT
Potent and selective inhibitor of SUV4-20
Chemical name
6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine
Parent CAS No.
[1982372-88-2]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
