axonmedchem/A 769662/5毫克/轴突1466
商品编号：
Axon1466
品牌：
axon medch
市场价：
¥1700.00
美元价：
850.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
A 769662
Axon 1466
CAS [844499-71-4]
MF C20H12N2O3SMW 360.39
- Purity:99%
- Soluble in DMSO
Description
Potent and selective activator of AMP-activated protein kinase (AMPK) β1 subunit-containing complexes
| B Cool et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metabolism. 2006, 3, 403. |
| M Sanders et al. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J. Biol. Chem. 2007, 282, 32539. |
| O Göransson et al. Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase. J. Biol. Chem. 2007, 282, 32549-32560. |
| JW Scott et al. Thienopyridone drugs are selective activators of AMP-activated protein kinase β1-containing complexes. Chem. Biol. 2008, 15, 1220. |
| JT Treebak et al. A-769662 activates AMPK β1-containing complexes but induces glucose uptake through a PI3 kinase-dependent pathway in mouse skeletal muscle. Am. J. Physiol. Cell Physiol. 2009, 297(4), C1041-C1052. |
- Certificate of Analysis
- Material Safety Data Sheet
Cell Signaling & OncologyDiabetes & MetabolismStem CellAMPKPI3K-Akt-mTOREC 2.7.11.31
AMPK activator
Chemical name
6,7-Dihydro-4-hydroxy-3-(2"-hydroxy[1,1"-biphenyl]-4-yl )-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Parent CAS No.
[844499-71-4]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
