axonmedchem/3PO/10毫克/轴突2175
商品编号：
Axon2175
品牌：
axon medch
市场价：
¥1300.00
美元价：
650.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
3PO
Axon 2175
CAS [18550-98-6]
MF C13H10N2OMW 210.23
- Purity:99%
- Soluble in DMSO
Description
Inhibitor of HIF-1-induced PFKFB3, an enzyme with a key role in glycolysis. Potential application as suppressor of tumor glucose metabolism and growth of non-small cell lung cancer cells. The PFKFB3 family member has the highest kinase:bisphosphatase ratio (740:1) of the four known PFKFB family members. 3PO markedly attenuated the stimulation of F2,6BP synthesis, 2-[1-14C]-deoxy-D-glucose uptake, lactate secretion, TNF-α secretion and T cell aggregation and proliferation.
KEYWORDS: 3PO | supplier | PFKFB3 inhibitor | 3PO | 3PO | CAS [18550-98-6] | Fructose 6-phosphate | PFKFB3 | F6P | F2 | 6BP | Inhibitor | Enzymes
| S Telang et al. Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation. J. Trans. Med. 2012, 10, 95. |
| B Clem et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol. Cancer. Ther. 2008, 7, 110-120. |
- Certificate of Analysis
- Material Safety Data Sheet
Cell Signaling & OncologyDiabetes & MetabolismImmunologyPFKFB3NF-κBEC 2.7.1.105
Inhibitor of HIF-1-induced PFKFB3, an enzyme with a key role in glycolysis.
Chemical name
(E)-3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one
Parent CAS No.
[18550-98-6]
品牌介绍
荷兰Axon Medchem BV公司从Axon Biochemicals BV剥离出来，是欧洲＊＊的化学服务平台，专业从事合同研究和高品质的生物活性和/或药物类似分子的合成。Axon Medchem连同Axon Biochemicals公司作为医药化学领域的合同研究组织（CRO）进行商业运作。 Axon Medchem也是高价值的生命科学产品的主要来源，提供药品研究用的Axon Ligands (TM)系列。
